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Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to manage pain and inflammation. However, it carries certain risks and precautions that need to be considered. Below are important safety details that you should be aware of:

• Heart Risks: Meloxicam may increase the risk of heart attack or stroke, especially with prolonged use. The risk is higher in older adults and those with pre-existing heart conditions or risk factors such as high blood pressure, diabetes, or smoking. Avoid using this medication right before or after heart bypass surgery (CABG).

• Stomach and Intestinal Bleeding: This medication can cause serious bleeding in the stomach or intestines at any time during treatment. The risk is greater in older adults and those with a history of stomach issues. Certain medications, such as aspirin, other NSAIDs, corticosteroids, antidepressants, and blood thinners, can increase this risk. If you experience symptoms like persistent stomach pain, bloody or dark stools, or vomit resembling coffee grounds, seek medical attention immediately.

• High Blood Pressure and Heart Failure: Meloxicam may elevate blood pressure or contribute to heart failure due to fluid retention. Monitor your blood pressure regularly and report any significant changes to your healthcare provider.

• Liver Problems: In rare cases, meloxicam can cause serious liver issues. Symptoms such as abdominal swelling, yellowing of the skin or eyes, dark urine, or confusion should be addressed with a healthcare provider promptly.

• Kidney Damage and High Potassium Levels: This medication can impair kidney function, particularly in individuals with pre-existing kidney or liver problems, heart failure, or those taking certain blood pressure medications. If you notice changes in urination frequency, consult your healthcare provider.

• Severe Allergic Reactions: Severe allergic reactions, including anaphylaxis, are possible. Seek immediate medical help if you experience hives, swelling of the lips or tongue, or difficulty breathing. Those with allergies to aspirin or other NSAIDs should exercise caution.

• Asthma Attacks: Meloxicam can trigger severe asthma attacks, especially in those with a history of asthma or allergic reactions to aspirin or NSAIDs. Immediate medical attention is required if breathing difficulties occur.

• Pregnancy Risks: Use of meloxicam during the second half of pregnancy may harm the unborn baby or cause complications during delivery. Discuss potential risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.

Contraindications:

• Do not use meloxicam if you have a history of asthma, hives, or other allergic reactions to aspirin or other NSAIDs.
• Avoid meloxicam use following coronary artery bypass graft surgery (CABG).

Always discuss your medical history and any medications you are taking with your healthcare provider to ensure safe use of meloxicam. If you suspect an overdose or experience severe side effects, seek immediate medical assistance.

Common side effects:

• Stomach upset
• Diarrhea
• Headache
• Joint pain
• Flu-like symptoms
• Urinary tract infections
• Mild swelling

Less common but important to monitor:

• Constipation
• Low red blood cell count
• Liver damage
• Increase in blood pressure

Serious side effects:

• Severe dizziness
• Skin rashes
• Swelling of the face or throat
• Trouble breathing
• Fever
• Persistent nausea
• Loss of appetite
• Dark urine
• Yellowing of the skin or eyes
• Swelling in the ankles or feet
• Unusual tiredness

Interactions with high risk of serious adverse effects and should be avoided:

• Anti-platelet drugs such as clopidogrel
• Blood thinners such as dabigatran, enoxaparin, warfarin
• Sodium polystyrene sulfonate (if taking liquid meloxicam)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aliskiren
• ACE inhibitors such as captopril, lisinopril
• Angiotensin II receptor blockers such as losartan, valsartan
• Cidofovir
• Lithium
• Methotrexate (high-dose treatment)
• Diuretics such as furosemide
• NSAIDs such as celecoxib, ibuprofen, ketorolac