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This document outlines critical safety warnings and precautions associated with the use of aspirin. Please read these warnings carefully and consult your healthcare provider if you have any questions or concerns.

• Stomach Issues: Aspirin can cause stomach irritation, leading to pain, heartburn, or more severe conditions like bleeding and ulcers. This risk increases if you are taking blood thinners or oral corticosteroids. Be vigilant for symptoms such as persistent stomach pain, vomiting blood, or black, tarry stools, and inform your healthcare provider immediately if they occur. Higher risk factors include individuals over 60, those with a history of stomach issues, bleeding problems, those consuming more than three alcoholic beverages a day, and those taking aspirin longer or at higher doses than recommended.

• Kidney Concerns: Aspirin doses of 325 mg or more can reduce kidney blood flow, potentially causing damage, particularly in individuals with existing kidney, liver, or heart conditions. If you notice decreased urination, fever, muscle weakness, numbness, or a rapid heartbeat, discontinue use and contact your healthcare provider. Those at greater risk include individuals with kidney or liver history, heart failure, those taking specific blood pressure medications, and individuals over 65.

• Reye's Syndrome in Children: Children recovering from viral infections who take aspirin face the risk of developing Reye's syndrome, a rare but life-threatening condition. Symptoms include vomiting, sleepiness, confusion, and rapid breathing. Immediate medical attention is crucial if these symptoms appear. Avoid giving aspirin to children 18 years or younger recovering from flu-like symptoms.

• Pregnancy Risks: Pregnant individuals, particularly those 20 weeks or more along, should avoid taking aspirin at doses of 325 mg or higher due to potential harm to the unborn baby's growth, kidneys, and heart. Discuss safer alternatives with your healthcare provider.

• Allergic Reactions: Although uncommon, aspirin can cause severe allergic reactions, including hives, facial swelling, and wheezing, as well as severe skin reactions like rashes and blistering. Discontinue use and seek emergency medical help if these occur.

• Dosage Awareness: Ensure that you are taking the prescribed aspirin dosage. If your healthcare provider advises low-dose aspirin (81 mg per day), do not exceed this, as higher doses may not have the same benefits and could increase the risk of side effects.

• Contraindications: Do not use aspirin if you are allergic to it or any other pain or fever relievers. Always consult your healthcare provider before using aspirin if you have any allergies or pre-existing conditions.

When using this medication, some individuals may experience mild side effects such as upset stomach or heartburn. These effects are generally not serious, but if they persist or worsen, it is advisable to consult a healthcare provider.

More serious side effects, though less common, require prompt medical attention. These include severe or unrelenting nausea and vomiting, easy bruising or bleeding, difficulty hearing or ringing in the ears, and signs of kidney problems like changes in urine output. Additionally, unexplained tiredness, dizziness, and dark urine may also occur. Rarely, serious stomach or intestinal bleeding can happen, indicated by severe abdominal pain, black or tarry stools, or vomit resembling coffee grounds.

In extremely rare cases, severe allergic reactions can occur, with symptoms such as fever, swollen lymph nodes, rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, and breathing difficulties. Other rare but serious conditions include Reye's syndrome, which presents with vomiting, confusion, or seizures, and potential liver or kidney injury, which may manifest as changes in urine output or yellowing of the skin or eyes.

If you experience any of these severe side effects or others not listed, it is crucial to seek medical help immediately. Always communicate with your healthcare provider regarding any concerns about side effects.

Before using this medication, it's important to be aware of potential interactions with other substances. Some drugs that may interact include mifepristone, acetazolamide, blood thinners like warfarin and heparin, corticosteroids such as prednisone, dichlorphenamide, methotrexate, valproic acid, and herbal supplements like ginkgo biloba. Additionally, if you have recently received live vaccines, such as the varicella or live flu vaccine, discuss this with your doctor.

Be sure to review all your medicine labels, both prescription and over-the-counter, as many contain pain relievers or fever reducers like aspirin and NSAIDs (ibuprofen, ketorolac, naproxen). These are similar to this medication and using them together can increase the risk of side effects. Particularly, daily use of NSAIDs might reduce aspirin’s effectiveness in preventing heart attacks or strokes. If you're on low-dose aspirin for such preventive measures, consult your healthcare provider to explore alternatives like acetaminophen for managing pain or fever.

Moreover, this medication can affect certain laboratory tests, such as some urine sugar tests, leading to inaccurate results. Inform lab personnel and all your healthcare providers that you are taking this drug to prevent misinterpretation of test outcomes.