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Please review the following important safety information regarding the use of Cortifoam (hydrocortisone). If you have any concerns, it is essential to consult your healthcare provider.

• Heart and Kidney Concerns: Higher doses of corticosteroids like Cortifoam can elevate blood pressure, cause fluid retention, and disrupt electrolyte balance, leading to swelling. A low-salt diet and supplements may be necessary. Consult your healthcare provider if you have kidney issues or notice swelling. Risks include high corticosteroid doses, kidney problems, and recent heart attacks.

• Hormonal Effects: Prolonged use or high doses of Cortifoam can reduce natural stress hormone production, causing symptoms like weakness and nausea if stopped suddenly. Consult your provider on tapering off safely. Risks include long-term use, high doses, and thyroid issues.

• Gastrointestinal Risks: Inform your provider about any stomach or intestinal damage or recent surgeries, as Cortifoam can exacerbate these conditions, causing symptoms like nausea and bloody diarrhea. Risks include stomach ulcers, intestinal damage, and recent surgeries.

• Bone Health: Long-term or high-dose use of Cortifoam can lead to bone weakening. Consult your provider if you are at risk for bone loss. Risks involve menopause, extended corticosteroid use, and high doses.

• Mood and Muscle Effects: Though rare, Cortifoam can impact mood and muscles, causing symptoms like limb weakness or mood swings. Report these to your provider. Risks include medications affecting mood or muscles.

• Infection Risk: Cortifoam may weaken your immune system, masking infection symptoms. Contact your provider if you suspect an infection or have traveled to high-risk areas. Symptoms include fever and breathing difficulties.

• Vaccination Advisory: Avoid live or live-attenuated vaccines while using Cortifoam. Killed vaccines, like the flu shot, are safe. Inform your provider or pharmacist about Cortifoam use before getting vaccinated. Risk is higher with increased corticosteroid doses.

• Vision Issues: Rarely, Cortifoam can affect vision, potentially causing cataracts, glaucoma, or eye infections. Consult your provider if you have eye problems, especially with long-term use.

Contraindications: Do not use Cortifoam if you have rectal blockage, abscess, perforation, stomach lining inflammation, or recent intestinal procedures. Consult your healthcare provider if any of these conditions apply to you.

When using this medication, you may experience some mild or common side effects such as itching or burning in the rectum, skin bruising, and skin thinning. These effects are generally not serious, but if they persist or worsen, it's important to consult with a healthcare professional for advice and reassurance. Additionally, some individuals might experience rectal pain or burning, dizziness, feeling bloated, swelling, or difficulty sleeping. Again, these are typically mild but should be monitored.

On the more serious side, though rare, certain side effects can occur that require immediate medical attention. These include unusual or extreme tiredness, weight loss, headaches, swelling of the ankles or feet, increased thirst or urination, and vision problems. Other severe symptoms may include rectal bleeding, unusual bruising or bleeding, signs of stomach or intestinal bleeding such as stomach pain, black or tarry stools, or vomit that resembles coffee grounds. Furthermore, symptoms like bone pain, easily broken bones, mental or mood changes, muscle weakness or pain, irregular heartbeat, and signs of infection (persistent sore throat, fever, painful urination, worsening redness or irritation near the anus) should be addressed urgently.

In extremely rare cases, a very serious allergic reaction may occur. This includes symptoms such as rash, itching or swelling especially of the face, tongue, or throat, severe dizziness, and trouble breathing. If any of these occur, seek immediate medical help. Always communicate any side effects to a healthcare provider to ensure safe and effective use of the medication.