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This safety information outlines important warnings and precautions for the use of mesalamine (Canasa). Please read the following points carefully and discuss any concerns with your healthcare provider.

• Kidney Damage and Stones: Mesalamine can potentially harm your kidneys. This risk increases if you have existing kidney conditions or are taking medications such as NSAIDs and diuretics that may affect the kidneys. Regular blood or urine tests may be required to monitor kidney function. Contact your healthcare provider if you experience changes in urination, fatigue, loss of appetite, or muscle cramps.

• Acute Intolerance Syndrome: Although rare, some individuals may experience acute intolerance syndrome within 1 to 3 weeks of starting mesalamine. Symptoms typically resolve a few days after discontinuing the medication or initiating corticosteroid treatment.

• Severe Allergic Reactions: Mesalamine can cause serious allergic reactions, including anaphylaxis, characterized by facial swelling, shock, and throat closure. Seek immediate emergency assistance if you notice hives, rash, swelling of the lips or tongue, or difficulty breathing.

• Severe Skin Reactions: Mesalamine may lead to rare but severe skin conditions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and DRESS syndrome. Discontinue use and seek medical attention if you experience unusual skin changes like rashes, blisters, peeling, or redness, which may be accompanied by fever, sore throat, fatigue, or swollen lymph nodes.

• Liver Problems: Individuals with liver conditions may be at risk of liver failure when taking mesalamine. Inform your healthcare provider of any liver history before starting treatment. Seek immediate medical care if you experience severe nausea, vomiting, right-sided abdominal pain, fatigue, loss of appetite, or jaundice.

• Sun Sensitivity: Those with skin conditions such as eczema may experience increased sensitivity to sunlight and UV light, leading to easier sunburns, even in winter or cloudy conditions.

Contraindications

• Allergy to Aspirin or Salicylates: Do not use mesalamine if you have known allergies to aspirin or other salicylates, as it may pose serious health risks. Consult your healthcare provider if this applies to you.

Please ensure you follow these guidelines to minimize risks and manage any potential side effects effectively.

When using this medication, some individuals may experience mild side effects, including rectal pain, pain during suppository insertion, headache, gas, stomach pain, diarrhea, dizziness, and acne. These symptoms are generally not serious, but if they persist or worsen, consulting with a healthcare provider is advisable to ensure safety and comfort.

There are also other side effects reported by users that could be more concerning. These include fever, rash, and inflammation in the colon, which may lead to diarrhea. If you experience any of these symptoms, particularly if they are severe, contacting your healthcare provider is recommended.

In rare cases, this medication can cause serious side effects that require immediate medical attention. These include symptoms of kidney damage such as reduced urination, dry and itchy skin, muscle cramps, and swelling in the extremities; kidney stones evidenced by difficulty urinating, bloody urine, and back or side pain; and liver problems such as stomach bloating, right-sided stomach pain, yellowing of the skin or eyes, and dark urine. Serious allergic reactions may occur, presenting with fever, swollen lymph nodes, rash, swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. Additionally, serious skin reactions like hives, blisters, peeling skin, and skin reddening should be addressed urgently.

While most individuals do not experience severe side effects, it is crucial to monitor for these signs and seek medical help promptly should they occur. Always report any new or unexpected symptoms to your healthcare provider.